Synold, Timothy : rechercher sur Z-Library

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1

Pharmacokinetics of vincristine in children and adolescents with acute lymphocytic leukemia

William R. Crom, Siebold S.N. de Graaf, Timothy Synold, Donald R.A. Uges, Henk Bloemhof, Gaston Rivera, Michael L. Christensen, Hazem Mahmoud, William E. Evans

Journal:

The Journal of Pediatrics

Année:

1994

Langue:

english

Fichier:

PDF, 600 KB

english, 1994

2

A phase I trial of mushroom powder in patients with biochemically recurrent prostate cancer: Roles of cytokines and myeloid-derived suppressor cells for Agaricus bisporus -induced prostate-specific antigen responses

Twardowski, Przemyslaw, Kanaya, Noriko, Frankel, Paul, Synold, Timothy, Ruel, Christopher, Pal, Sumanta K., Junqueira, Maribel, Prajapati, Manisha, Moore, Tina, Tryon, Pamela, Chen, Shiuan

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 255 KB

english, 2015

3

Prevention of early renal disease, dyslipidaemia and lipid peroxidation in STZ-diabetic rats by LR-9 and LR-74, novel AGE inhibitors

James Lester Figarola, Steven Scott, Sofia Loera, Bixin Xi, Timothy Synold, Lawrence Weiss, Dr Samuel Rahbar

Journal:

Diabetes/Metabolism Research and Reviews

Année:

2005

Langue:

english

Fichier:

PDF, 372 KB

english, 2005

4

A phase II and pharmacokinetic study of SB-715992, in patients with metastatic hepatocellular carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG IND.168)

Jennifer J. Knox, Sharlene Gill, Timothy W. Synold, James J. Biagi, Pierre Major, Ron Feld, Christine Cripps, Nancy Wainman, Elizabeth Eisenhauer, Lesley Seymour

Journal:

Investigational New Drugs

Année:

2008

Langue:

english

Fichier:

PDF, 338 KB

english, 2008

5

A phase II study of ispinesib (SB-715992) in patients with metastatic or recurrent malignant melanoma: a National Cancer Institute of Canada Clinical Trials Group trial

Christopher W. Lee, Karl Bélanger, Sanjay C. Rao, Teresa M. Petrella, Richard G. Tozer, Lori Wood, Kerry J. Savage, Elizabeth A. Eisenhauer, Timothy W. Synold, Nancy Wainman, Lesley Seymour

Journal:

Investigational New Drugs

Année:

2008

Langue:

english

Fichier:

PDF, 145 KB

english, 2008

6

Inhibition of MDR1 Overcomes Resistance to Brentuximab Vedotin in Hodgkin Lymphoma

Chen, Robert, Herrera, Alex F., Hou, Jessie, Chen, Lu, Wu, Jun, Guo, Yuming, Synold, Timothy W., Ngo, Vu N., Puverel, Sandrine, Mei, Matthew, Popplewell, Leslie, Yi, Shuhua, Song, Joo Y., Tao, Shu, Wu

Journal:

Clinical Cancer Research

Année:

2019

Langue:

english

Fichier:

PDF, 1018 KB

english, 2019

7

Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase

Qiang Gao, R. Steven Esworthy, Byung-Wook Kim, Timothy W. Synold, David D. Smith, Fong-Fong Chu

Journal:

Inflammatory Bowel Diseases

Année:

2010

Langue:

english

Fichier:

PDF, 3.20 MB

english, 2010

8

Simple and sensitive method for the quantitative analysis of lometrexol in plasma using high-performance liquid chromatography with electrochemical detection

Timothy W. Synold, Bixin Xi, Edward M. Newman, Franco M. Muggia, James H. Doroshow

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1996

Langue:

english

Fichier:

PDF, 374 KB

english, 1996

9

Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors

Peter J. Houghton, Pamela J. Cheshire, Leann Myers, Clinton F. Stewart, Timothy W. Synold, Janet A. Houghton

Journal:

Cancer Chemotherapy and Pharmacology

Année:

1992

Langue:

english

Fichier:

PDF, 1.06 MB

english, 1992

10

Phase I pharmacodynamic study of time and sequence dependency of hydroxyurea in combination with gemcitabine: a California Cancer Consortium Trial

Yun Yen, Warren Chow, Lucille Leong, Kim Margolin, Robert Morgan, James Raschko, Stephen Shibata, George Somlo, Przemyslaw Twardowski, Paul Frankel, Jeff Longmate, Timothy Synold, Edward M. Newman, He

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 196 KB

english, 2002

11

Feasibility and pharmacokinetic study of infusional dexrazoxane and dose-intensive doxorubicin administered concurrently over 96

Warren A. Chow, Timothy W. Synold, Merry L. Tetef, Jeffrey Longmate, Paul Frankel, Joyce Lawrence, Zaid Al-Khadimi, Lucille Leong, Dean Lim, Kim Margolin, Robert J. Morgan, James Raschko, Stephen Shib

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 216 KB

english, 2004

12

Phase II trial of carboplatin and infusional cyclosporine in platinum-resistant recurrent ovarian cancer

Robert J. Morgan, Timothy W. Synold, David Gandara, Franco Muggia, Sidney Scudder, Eddie Reed, Kim Margolin, James Raschko, Lucille Leong, Stephen Shibata, Merry Tetef, Steven Vasilev, Kathryn McGonig

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 215 KB

english, 2004

13

A phase I study of oxaliplatin in combination with gemcitabine: correlation of clinical outcome with gene expression

Stephen Shibata, Warren Chow, Paul Frankel, Agnes Juhasz, Lucille Leong, Dean Lim, Kim Margolin, Robert Morgan, Edward Newman, George Somlo, Yun Yen, Timothy Synold, David Gandara, Heinz-Josef Lenz, J

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 386 KB

english, 2007

14

Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU)

Jan H. Beumer, Robert A. Parise, Edward M. Newman, James H. Doroshow, Timothy W. Synold, Heinz-Josef Lenz, Merrill J. Egorin

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 321 KB

english, 2008

15

Phase I trial of GTI-2040, oxaliplatin, and capecitabine in the treatment of advanced metastatic solid tumors: a California Cancer Consortium Study

Stephen I. Shibata, James H. Doroshow, Paul Frankel, Timothy W. Synold, Yun Yen, David R. Gandara, Heinz-Josef Lenz, Warren A. Chow, Lucille A. Leong, Dean Lim, Kim A. Margolin, Robert J. Morgan, Geor

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 310 KB

english, 2009

16

Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors

Robert J. Morgan, Timothy Synold, Adam Mamelak, Dean Lim, Zaid Al-Kadhimi, Przemyslaw Twardowski, Lucille Leong, Warren Chow, Kim Margolin, Stephen Shibata, George Somlo, Yun Yen, Paul Frankel, James

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 258 KB

english, 2010

17

A phase I and pharmacokinetic study of oral 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced-stage solid cancers: a California Cancer Consortium Study

Joseph Chao, Timothy W. Synold, Robert J. Morgan, Charles Kunos, Jeff Longmate, Heinz-Josef Lenz, Dean Lim, Stephen Shibata, Vincent Chung, Ronald G. Stoller, Chandra P. Belani, David R. Gandara, Mark

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2012

Langue:

english

Fichier:

PDF, 259 KB

english, 2012

18

A phase I study of carboplatin and etoposide administered in conjunction with dipyridamole, prochlorperazine and cyclosporine A

James W. Raschko, Timothy W. Synold, Warren Chow, Paul Coluzzi, Victor Hamasaki, Lucille A. Leong, Kim A. Margolin, Robert J. Morgan, Stephen I. Shibata, George Somlo, Merry L. Tetef, Yun Yen, Anna te

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 124 KB

english, 2000

19

Continuous infusion prochlorperazine: pharmacokinetics, antiemetic efficacy, and feasibility of high-dose therapy

Robert J. Morgan Jr, Timothy Synold, Brian I. Carr, James H. Doroshow, Eleanor P. Womack, Stephen Shibata, George Somlo, James Raschko, Lucille Leong, Mark McNamara, Warren Chow, Merry Tetef, Kim Marg

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 145 KB

english, 2001

20

Weekly lometrexol with daily oral folic acid is appropriate for phase II evaluation

John D. Roberts, Elizabeth A. Poplin, Mary Beth Tombes, Brenda Kyle, Darcy V. Spicer, Steven Grant, Timothy Synold, Richard Moran

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 116 KB

english, 2000

21

High-dose toremifene as a cisplatin modulator in metastatic non-small cell lung cancer: targeted plasma levels are achievable clinically

Primo N. Lara Jr., David R. Gandara, Gregory T. Wurz, Derick Lau, Margaret Uhrich, Corinne Turrell, James Raschko, Martin J. Edelman, Timothy Synold, James Doroshow, Franco Muggia, Edith A. Perez, Mik

Journal:

Cancer Chemotherapy and Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 136 KB

english, 1998

22

Oblimersen and α-interferon in metastatic renal cancer: a phase II study of the California Cancer Consortium

Kim Margolin, Timothy W. Synold, Primo Lara, Paul Frankel, Simon F. Lacey, David I. Quinn, Tracey Baratta, Janice P. Dutcher, Bixin Xi, Don J. Diamond, David R. Gandara

Journal:

Journal of Cancer Research and Clinical Oncology

Année:

2007

Langue:

english

Fichier:

PDF, 277 KB

english, 2007

23

Phase II study of ispinesib in recurrent or metastatic squamous cell carcinoma of the head and neck

Patricia A. Tang, Lillian L. Siu, Eric X. Chen, Sebastien J. Hotte, Stephen Chia, James K. Schwarz, Gregory R. Pond, Caitlin Johnson, A. Dimitrios Colevas, Timothy W. Synold, Lakshmi S. Vasist, Eric W

Journal:

Investigational New Drugs

Année:

2008

Langue:

english

Fichier:

PDF, 262 KB

english, 2008

24

The Effect of Height on Paclitaxel Nerve Damage

Harry Openshaw, Karen Beamon, Jeffrey Longmate, Timothy Synold, Neal E. Slatkin, George Somlo

Journal:

Journal of Neuro-Oncology

Année:

2005

Langue:

english

Fichier:

PDF, 254 KB

english, 2005

25

10.1038/87912

Synold, Timothy W., Dussault, Isabelle, Forman, Barry Marc

Journal:

Nature Medicine

Année:

2001

Langue:

english

Fichier:

PDF, 634 KB

english, 2001

26

Renoprotective and Lipid-Lowering Effects of LR Compounds, Novel Advanced Glycation End Product Inhibitors, in Streptozotocin-Induced Diabetic Rats

JAMES LESTER FIGAROLA, STEVEN SCOTT, SOFIA LOERA, BIXIN XI, TIMOTHY SYNOLD, SAMUEL RAHBAR

Journal:

Annals of the New York Academy of Sciences

Année:

2005

Langue:

english

Fichier:

PDF, 3.74 MB

english, 2005

27

Dolastatin-10 in Metastatic Melanoma: A Phase II and Pharmokinetic Trial of the California Cancer Consortium

Kim Margolin, Jeffrey Longmate, Timothy W. Synold, David R. Gandara, Jeffrey Weber, Rene Gonzalez, Mary J. Johansen, Robert Newman, Tracey Baratta, James H. Doroshow

Journal:

Investigational New Drugs

Année:

2001

Langue:

english

Fichier:

PDF, 72 KB

english, 2001

28

Validation of a Limited Sampling Model to Determine Etoposide Area Under the Curve

Bert L. Lum, Kevin J. Lane, Timothy W. Synold, Adrian Goram, Steven B. Charnick, Branimir I. Sikic

Journal:

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Année:

1997

Langue:

english

Fichier:

PDF, 381 KB

english, 1997

29

Pharmacology of oxaliplatin in solid tumor patients with hepatic dysfunction: a preliminary report of the national cancer institute organ dysfunction working group

James H Doroshow, Timothy W Synold, David Gandara, Sridhar Mani, Scot C Remick, Daniel Mulkerin, Anne Hamilton, Sunil Sharma, Ramesh K Ramanathan, Heinz Josef Lenz, Martin Graham, Jeffrey Longmate, Ch

Journal:

Seminars in Oncology

Année:

2003

Langue:

english

Fichier:

PDF, 114 KB

english, 2003

30

Southwest Oncology Group Phase II Study of Ispinesib in Androgen-Independent Prostate Cancer Previously Treated with Taxanes

Tomasz M. Beer, Bryan Goldman, Timothy W. Synold, Christopher W. Ryan, Lakshmi S. Vasist, Peter J. Van Veldhuizen Jr, Shaker R. Dakhil, Primo N. Lara Jr, Anibal Drelichman, Maha H.A. Hussain, E. David

Journal:

Clinical Genitourinary Cancer

Année:

2008

Langue:

english

Fichier:

PDF, 1.69 MB

english, 2008

31

Effects of iodonium-class flavin dehydrogenase inhibitors on growth, reactive oxygen production, cell cycle progression, NADPH oxidase 1 levels, and gene expression in human colon cancer cells and xenografts

Doroshow, James H., Gaur, Shikha, Markel, Susan, Lu, Jiamo, van Balgooy, Josephus, Synold, Timothy W., Xi, Bixin, Wu, Xiwei, Juhasz, Agnes

Journal:

Free Radical Biology and Medicine

Année:

2013

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2013

32

Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice

Timothy W. Synold, Bixin Xi, Jun Wu, Yun Yen…

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2012

Langue:

english

Fichier:

PDF, 465 KB

english, 2012

33

Biologic Markers of Angiogenesis: Circulating Endothelial Cells in Patients with Advanced Malignancies Treated on Phase I Protocol with Metronomic Chemotherapy and Celecoxib

Twardowski, Przemyslaw W., Smith-Powell, Leslie, Carroll, Mary, VanBalgooy, J., Ruel, Christopher, Frankel, Paul, Synold, Timothy W.

Journal:

Cancer Investigation

Année:

2008

Langue:

english

Fichier:

PDF, 2.13 MB

english, 2008

34

Phase I study evaluating the combination of lapatinib (a Her2/Neu and EGFR inhibitor) and everolimus (an mTOR inhibitor) in patients with advanced cancers: South West Oncology Group (SWOG) Study S0528

Gadgeel, Shirish M., Lew, Danika L., Synold, Timothy W., LoRusso, Patricia, Chung, Vincent, Christensen, Scott D., Smith, David C., Kingsbury, Laura, Hoering, Antje, Kurzrock, Razelle

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2013

Langue:

english

Fichier:

PDF, 400 KB

english, 2013

35

A neuropharmacokinetic assessment of bafetinib, a second generation dual BCR-Abl/Lyn tyrosine kinase inhibitor, in patients with recurrent high-grade gliomas

Portnow, Jana, Badie, Behnam, Markel, Susan, Liu, An, D’Apuzzo, Massimo, Frankel, Paul, Jandial, Rahul, Synold, Timothy W.

Journal:

European Journal of Cancer

Année:

2013

Langue:

english

Fichier:

PDF, 374 KB

english, 2013

36

A pilot microdialysis study in brain tumor patients to assess changes in intracerebral cytokine levels after craniotomy and in response to treatment with a targeted anti-cancer agent

Portnow, Jana, Badie, Behnam, Liu, Xueli, Frankel, Paul, Mi, Shu, Chen, Mike, Synold, Timothy W.

Journal:

Journal of Neuro-Oncology

Année:

2014

Langue:

english

Fichier:

PDF, 296 KB

english, 2014

37

Iron chelators induce autophagic cell death in multiple myeloma cells

Pullarkat, Vinod, Meng, Zhuo, Donohue, Cecile, Yamamoto, Vicky N., Tomassetti, Sarah, Bhatia, Ravi, Krishnan, Amrita, Forman, Stephen J., Synold, Timothy W.

Journal:

Leukemia Research

Année:

2014

Langue:

english

Fichier:

PDF, 2.28 MB

english, 2014

38

Similar Mutagenicity of Photoactivated Porphyrins and Ultraviolet A Radiation in Mouse Embryonic Fibroblasts: Involvement of Oxidative DNA Lesions in Mutagenesis †

Besaratinia, Ahmad, Bates, Steven E., Synold, Timothy W., Pfeifer, Gerd P.

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 467 KB

english, 2004

39

G-to-T Transversions and Small Tandem Base Deletions Are the Hallmark of Mutations Induced by Ultraviolet A Radiation in Mammalian Cells †

Besaratinia, Ahmad, Synold, Timothy W., Xi, Bixin, Pfeifer, Gerd P.

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 213 KB

english, 2004

40

Advanced Glycation End Products of DNA: Quantification of N 2 -(1-Carboxyethyl)-2′-deoxyguanosine in Biological Samples by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

Synold, Timothy, Xi, Bixin, Wuenschell, Gerald E., Tamae, Daniel, Figarola, James L., Rahbar, Samuel, Termini, John

Journal:

Chemical Research in Toxicology

Année:

2008

Langue:

english

Fichier:

PDF, 561 KB

english, 2008

41

Role of Folylpolygutamate Synthetase (FPGS) in Antifolate Chemotherapy; a Biochemical and Clinical Update

Synold, Timothy W., Willits, Elizabeth M., Barredo, Julio C.

Journal:

Leukemia and Lymphoma

Année:

1996

Langue:

english

Fichier:

PDF, 735 KB

english, 1996

42

Population pharmacokinetic analysis of oxaliplatin in adults and children identifies important covariates for dosing

Nikanjam, Mina, Stewart, Clinton F., Takimoto, Chris H., Synold, Timothy W., Beaty, Orren, Fouladi, Maryam, Capparelli, Edmund V.

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 872 KB

english, 2015

43

Human Granulocyte Colony-Stimulating Factor after Induction Chemotherapy in Children with Acute Lymphoblastic Leukemia

Pui, Ching-Hon, Boyett, James M., Hughes, Walter T., Rivera, Gaston K., Hancock, Michael L., Sandlund, John T., Synold, Timothy, Relling, Mary V., Ribeiro, Raul C., Crist, William M., Evans, William E

Journal:

Boston Medical and Surgical Journal

Année:

1997

Langue:

english

Fichier:

PDF, 111 KB

english, 1997

44

Pharmacodynamics (PD) and pharmacokinetics (PK) of E7389 (eribulin, halichondrin B analog) during a phase I trial in patients with advanced solid tumors: a California Cancer Consortium trial

Morgan, Robert J., Synold, Timothy W., Longmate, Jeffrey A., Quinn, David I., Gandara, David, Lenz, Heinz-Josef, Ruel, Christopher, Xi, Bixin, Lewis, Michael D., Colevas, A. Dimitrios, Doroshow, James

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 720 KB

english, 2015

45

A phase I pharmacodynamic study of GTI-2040, an antisense oligonucleotide against ribonuclotide reductase, in acute leukemias: a California Cancer Consortium study

Kirschbaum, Mark H., Frankel, Paul, Synold, Timothy W., Xie, Zhiliang, Yen, Yun, Popplewell, Leslie, Chen, Robert, Aljitawi, Omar, Tuscano, Joseph M., Chan, Kenneth K., Newman, Edward M.

Journal:

Leukemia and Lymphoma

Année:

2016

Langue:

english

Fichier:

PDF, 1001 KB

english, 2016

46

STEM-01NEURAL STEM CELL-MEDIATED ENZYME/PRODRUG THERAPY FOR NEUROBLASTOMA: TRANSLATION TO THE CLINIC

Gutova, Margarita, Goldstein, Leanne, Metz, Marianne, Hovsepyan, Anahit, Tsurkan, Lyudmila, Tirughana, Revathiswari, Wan, Zesheng, Synold, Timothy, Seegar, Robert, Anderson, Clarke, Potter, Philip, Mo

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 28 KB

english, 2015

47

Development of Population Pharmacokinetic Models and Optimal Sampling Times for Ibuprofen Tablet and Suspension Formulations in Children With Cystic Fibrosis

Beringer, Paul, Aminimanizani, Amir, Synold, Timothy, Scott, Christy

Journal:

Therapeutic Drug Monitoring

Année:

2002

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2002

48

A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: a California Cancer Consortium Study

Kirschbaum, Mark H., Frankel, Paul, Synold, Timothy W., Zain, Jasmine, Claxton, David, Tuscano, Joseph, Newman, Edward M., Gandara, David R., Lara, Primo N.

Journal:

British Journal of Haematology

Année:

2016

Langue:

english

Fichier:

PDF, 87 KB

english, 2016

49

Neural Stem Cell–Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients

Portnow, Jana, Synold, Timothy W., Badie, Behnam, Tirughana, Revathiswari, Lacey, Simon F., D'Apuzzo, Massimo, Metz, Marianne Z., Najbauer, Joseph, Bedell, Victoria, Vo, Tien, Gutova, Margarita, Frank

Journal:

Clinical Cancer Research

Année:

2016

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2016

50

20. Carboxylesterase-Secreting Neural Stem Cells Increase Efficacy of Irinotecan in Orthotopic Glioma Models: Translation Toward the Clinic

Ghoda, Lucy Y., Tirughana, Revathiswari, Gilchrist, Megan, Metz, Marianne, Gutova, Margarita, Khankaldyyan, Vazgen, Synold, Timothy, Blanchard, Suzette, D'Apuzzo, Massimo, Moats, Rex, Barish, Michael,

Journal:

Molecular Therapy

Année:

2015

Langue:

english

Fichier:

PDF, 430 KB

english, 2015